Okaramine B, an insecticidal indole alkaloid, produced by Penicillium simplicissimum AK-40.
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چکیده
منابع مشابه
GluCl a target of indole alkaloid okaramines: a 25 year enigma solved
In 1989, indole alkaloid okaramines isolated from the fermentation products of Penicillium simplicissimum were shown to be insecticidal, yet the mechanism of their toxicity to insects remains unknown. We therefore examined the action of okaramine B on silkworm larval neurons using patch-clamp electrophysiology. Okaramine B induced inward currents which reversed close to the chloride equilibrium...
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Four new okaramine congeners, okaramines J, K, L and M, were isolated from okara fermented with Penicillium simplicissimum ATCC 90288, together with five biogenetically related compounds, cyclo (8a-(α,α-dimethylallyl)-L-Trp-8a-(α,α-dimethylallyl)-L-Trp), cyclo (N (8)-(α,α-dimethylallyl)-L-Trp-6a'-(α,α-dimethylallyl)-L-Trp), cyclo (L-Trp-L-Trp), cyclo (6a'-(α,α-dimethylallyl)-L-Trp-L-Trp), and c...
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Growth of Penicillium simplicissimum on anisyl alcohol, veratryl alcohol or 4-(methoxymethyl)phenol, is associated with the synthesis of relatively large amounts of the hydrogen peroxide producing flavoprotein vanillyl-alcohol oxidase (VAO). Immunocytochemistry revealed that the enzyme has a dual location namely in peroxisomes and in the cytosol. The C-terminus of the primary structure of VAO d...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1988
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.52.2131